Kuşadası was annexed to the Ottoman rule by Mehmet I (Çelebi) in 1413. After this date, the city remained completely in the hands of the Turks and began to be filled with works made by the Turks. The walls surrounding today's Caravanserai and Kuşadası were built by Mehmet Pasha.

At that time, the walled city could only be entered through three gates. One of these gates separates Barbaros Hayrettin Pasha Street and Kahramanlar Street, and its upper part is used today as the Urban Traffic Regional Directorate. Other doors do not exist today.

Güvercinada, which served as an important military base for the Byzantines, underwent a major renovation in 1834 and its famous castle was built. The name "Kuşadası" comes from this castle.

Kuşadası was occupied by Italy between 1919 and 1921 during the War of Independence, and by Greece after their withdrawal, and was liberated from enemy occupation on September 7, 1922.